Estimates the negative charge contributed by albumin at a specified pH for Stewart acid–base analysis.
Albumin Weak-Acid Charge: Clinical Guide
Browse Knowledge HubEstimates the negative charge contributed by albumin at a specified pH for Stewart acid–base analysis. This premium guide explains physiology, calculation, interpretation, limitations and evidence.
Overview
Estimates the negative charge contributed by albumin at a specified pH for Stewart acid–base analysis.
Clinical Significance
Albumin is the major plasma weak acid; this value is used within selected Stewart implementations.
When to Use
- Calculate the albumin component of SIDe.
- Use contemporaneous albumin and pH.
- Apply within one consistent Stewart framework.
How It Is Calculated
- Albumin charge = albumin × (0.123 × pH − 0.631).
- MedicalC validates required values and rounds only the displayed result.
Interpretation
- Albumin is the major plasma weak acid; this value is used within selected Stewart implementations.
- Review source measurements, collection quality and clinical trajectory as well as the final value.
Worked Example
Enter clinically plausible values in the displayed units. MedicalC applies: Albumin charge = albumin × (0.123 × pH − 0.631). Verify the result against the source data before use.
Patient Considerations
- Consider kidney function, diuretics, intravenous fluids, nutrition, body composition and rapidly changing physiology.
- For timed urine calculations, confirm collection duration, volume and completeness.
- For electrolyte prescriptions, include all oral, enteral, intravenous and medication sources.
Limitations
- Published coefficients vary slightly.
- The model approximates protein charge.
- It is not independently diagnostic.
Clinical Pearls
- Use paired serum and urine values obtained as close together as possible when the formula requires them.
- A derived renal index is only as reliable as the collection and assays used.
- Check whether treatment occurred between sampling and interpretation.
Common Mistakes
- Mixing µmol/L and mmol/L creatinine values.
- Using spot concentrations as daily excretion rates.
- Ignoring incomplete timed urine collection.
- Treating a maintenance estimate as a replacement or emergency-correction regimen.
- Using a derived acid–base value without checking albumin, lactate and the blood gas.
Evidence Base
Principal source: Figge J, et al. The role of serum proteins in acid-base equilibria. J Lab Clin Med. 1991.
Frequently Asked Questions
What does the Albumin Weak-Acid Charge calculator do?
Estimates the negative charge contributed by albumin at a specified pH for Stewart acid–base analysis.
Can this result establish a diagnosis?
No. It is an adjunct that must be combined with clinical assessment and current guidance.
Why are timing and units important?
Derived results can be misleading when values are non-contemporaneous or use incompatible units.
When should the calculation be repeated?
Repeat when treatment, kidney function or the relevant measured values change and a new result could influence care.
Does this replace a specialist protocol?
No. Direct measurement, laboratory interpretation and specialist protocols take priority.
References
- Figge J, et al. The role of serum proteins in acid-base equilibria. J Lab Clin Med. 1991. — Primary publication, guideline or authoritative specialty source.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.