Calculates the pan-immune-inflammation value from neutrophils, monocytes, platelets and lymphocytes.
Overview
Calculates the pan-immune-inflammation value from neutrophils, monocytes, platelets and lymphocytes.
Clinical Significance
A research-oriented composite inflammatory index. It should not be used as a standalone diagnostic or treatment tool.
How It Is Calculated
- PIV = neutrophils × monocytes × platelets / lymphocytes.
Interpretation
- A research-oriented composite inflammatory index. It should not be used as a standalone diagnostic or treatment tool.
Worked Example
Enter a clinically consistent set of values in the displayed units. MedicalC applies: PIV = neutrophils × monocytes × platelets / lymphocytes.
Limitations
- This tool does not establish a diagnosis or mandate treatment.
- Published cut-offs may vary between cohorts and measurement methods.
- Calculation precision cannot compensate for poor source data.
Clinical Pearls
- Trend the result over time where clinically appropriate.
- Record the source values and units alongside the calculated result.
Common Mistakes
- Using the wrong unit.
- Combining measurements obtained at different times.
- Applying a research-derived threshold as a universal treatment trigger.
Frequently Asked Questions
What does this calculator provide?
Calculates the pan-immune-inflammation value from neutrophils, monocytes, platelets and lymphocytes.
Can this result be used alone?
No. It must be interpreted with clinical context and appropriate investigations.
What equation is used?
PIV = neutrophils × monocytes × platelets / lymphocytes.
What is the main limitation?
The result depends on valid inputs and may not be calibrated for every population or setting.
References
- Fucà G et al. The pan-immune-inflammation value in metastatic colorectal cancer. Br J Cancer. 2020. — Formula, physiological or validation reference.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026