Calculates bicarbonate from pH and arterial carbon dioxide tension using Henderson–Hasselbalch.
Calculated Bicarbonate from pH and PaCO₂: Clinical Guide
Browse Knowledge HubCalculates bicarbonate from pH and arterial carbon dioxide tension using Henderson–Hasselbalch.
Overview
Calculates bicarbonate from pH and arterial carbon dioxide tension using Henderson–Hasselbalch.
Clinical Significance
Reconstructs bicarbonate from blood-gas variables. Small differences from analyser-reported values may reflect rounding and analyser conventions.
When to Use
- Use when the required measurements are available, reliable and clinically relevant.
How It Is Calculated
- HCO₃⁻ = 0.03 × PaCO₂ × 10^(pH − 6.1).
Interpretation
- Reconstructs bicarbonate from blood-gas variables. Small differences from analyser-reported values may reflect rounding and analyser conventions.
Worked Example
Enter valid values in the displayed units. MedicalC then applies: HCO₃⁻ = 0.03 × PaCO₂ × 10^(pH − 6.1).
Limitations
- The result does not establish a diagnosis or mandate treatment.
- Measurement error may be more important than arithmetic precision.
- Published thresholds may differ between populations and settings.
Clinical Pearls
- Document the source values and units with the final result.
- Review trends rather than isolated values where appropriate.
Common Mistakes
- Using the wrong unit.
- Combining values from different time points.
- Applying the result outside the intended measurement or clinical context.
Frequently Asked Questions
What does this calculator provide?
Calculates bicarbonate from pH and arterial carbon dioxide tension using Henderson–Hasselbalch.
What formula is used?
HCO₃⁻ = 0.03 × PaCO₂ × 10^(pH − 6.1).
Can the result be used alone?
No. It must be interpreted with the full clinical assessment and appropriate investigations.
What is the main limitation?
The result depends on accurate source measurements, correct units and appropriate clinical applicability.
References
- Henderson LJ, Hasselbalch KA. Henderson–Hasselbalch acid–base relationship. — Primary, supporting or authoritative reference for the implemented relationship.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.