Corrected Sodium for Hyperglycaemia (Hillier): Clinical Guide

Overview

Calculates serum sodium corrected for hyperglycaemia using the Hillier correction factor.

Clinical Significance

Estimates sodium after accounting for the translocational effect of hyperglycaemia. The correction is approximate and should be interpreted with measured osmolality and clinical context.

When to Use

• Use when the required measurements are available, reliable and clinically relevant.

How It Is Calculated

• Corrected Na = measured Na + 2.4 × [(glucose mg/dL − 100) / 100].

Interpretation

• Estimates sodium after accounting for the translocational effect of hyperglycaemia. The correction is approximate and should be interpreted with measured osmolality and clinical context.

Worked Example

Enter valid values in the displayed units. MedicalC then applies: Corrected Na = measured Na + 2.4 × [(glucose mg/dL − 100) / 100].

Limitations

• The result does not establish a diagnosis or mandate treatment.
• Measurement error may be more important than arithmetic precision.
• Published thresholds may differ between populations and settings.

Clinical Pearls

• Document the source values and units with the final result.
• Review trends rather than isolated values where appropriate.

Common Mistakes

• Using the wrong unit.
• Combining values from different time points.
• Applying the result outside the intended measurement or clinical context.

References

1. Hillier TA et al. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999;106:399–403. — Primary, supporting or authoritative reference for the implemented relationship.