Platelet–Albumin–Bilirubin (PALBI) Grade: Clinical Guide

Overview

Calculates PALBI score and grade from bilirubin, albumin and platelet count.

Clinical Significance

Grade 1 indicates better preserved liver function than grades 2 or 3.

When to Use

• Use as decision support when all required inputs are reliable.

How It Is Calculated

• PALBI = 2.02log10 bilirubin −0.37(log10 bilirubin)² −0.04 albumin −3.48log10 platelets +1.01(log10 platelets)².

Interpretation

• Grade 1 indicates better preserved liver function than grades 2 or 3.

Worked Example

Enter verified values in the displayed units; MedicalC applies the published equation or point system.

Limitations

• Prediction models may be miscalibrated outside their derivation population.
• Measurement and classification error can materially change the result.

Clinical Pearls

• Document source values and units with the result.
• Use trends and the full clinical picture.

Common Mistakes

• Wrong units.
• Using non-contemporaneous inputs.
• Treating the output as a diagnosis or mandatory treatment decision.

References

1. Roayaie S et al. Hepatology. 2015;62 Suppl:631A. — Primary or supporting reference for the implemented model.