Estimates creatinine clearance in patients with obesity using the Salazar–Corcoran equation. This guide explains the formula, use and limitations.
Overview
Estimates creatinine clearance in patients with obesity using the Salazar–Corcoran equation.
Clinical Significance
The equation was developed in obesity and is not the preferred modern method for all patients or all drug labels.
When to Use
- Use when the calculation is relevant to the clinical question.
- Confirm that the population and units match the validated method.
- Use current and reliable measurements.
How It Is Calculated
- Sex-specific Salazar–Corcoran equation using age, weight, height and serum creatinine.
Interpretation
- The equation was developed in obesity and is not the preferred modern method for all patients or all drug labels.
- Interpret alongside the full clinical picture and current guidance.
Worked Example
Enter the required measurements in the stated units. MedicalC then applies: Sex-specific Salazar–Corcoran equation using age, weight, height and serum creatinine.
Patient Considerations
- Consider age, body size, pregnancy, organ function and treatment effects where relevant.
- Repeat the calculation when inputs or clinical status materially change.
Limitations
- Accuracy depends on the quality and units of the entered data.
- The equation may not be validated in every patient population.
- This tool does not replace clinical judgement or specialist advice.
Clinical Pearls
- Check units before calculating.
- Document the source and timing of each input.
- Use trends where clinically appropriate.
Common Mistakes
- Mixing SI and conventional units.
- Using non-contemporaneous measurements.
- Treating the output as a diagnosis or prescription.
Evidence Base
The implemented calculation follows the published or guideline-based relationship: Sex-specific Salazar–Corcoran equation using age, weight, height and serum creatinine.
Frequently Asked Questions
What does the Creatinine Clearance (Salazar–Corcoran) calculator do?
Estimates creatinine clearance in patients with obesity using the Salazar–Corcoran equation.
Can the result be used alone?
No. Use it as decision support with clinical assessment and current guidance.
Why might the result be misleading?
Incorrect units, poor measurement quality or use outside the validated population can produce misleading results.
Should it be recalculated?
Recalculate when relevant measurements or the clinical condition change.
References
- Salazar DE, Corcoran GB. Predicting creatinine clearance and renal drug clearance in obese patients. Clin Pharm. 1988. — Primary publication, guideline or established source supporting the calculation.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026