Free Androgen Index Calculator

Overview

Calculates the free androgen index from total testosterone and sex hormone-binding globulin.

Clinical Significance

The free androgen index is an indirect estimate of bioavailable androgen and should be interpreted with assay method, sex, age and clinical context.

When to Use

• Use when the calculation is relevant to the clinical question.
• Confirm that the population and units match the validated method.
• Use current and reliable measurements.

How It Is Calculated

• FAI = total testosterone ÷ SHBG × 100.

Interpretation

• The free androgen index is an indirect estimate of bioavailable androgen and should be interpreted with assay method, sex, age and clinical context.
• Interpret alongside the full clinical picture and current guidance.

Worked Example

Enter the required measurements in the stated units. MedicalC then applies: FAI = total testosterone ÷ SHBG × 100.

Patient Considerations

• Consider age, body size, pregnancy, organ function and treatment effects where relevant.
• Repeat the calculation when inputs or clinical status materially change.

Limitations

• Accuracy depends on the quality and units of the entered data.
• The equation may not be validated in every patient population.
• This tool does not replace clinical judgement or specialist advice.

Clinical Pearls

• Check units before calculating.
• Document the source and timing of each input.
• Use trends where clinically appropriate.

Common Mistakes

• Mixing SI and conventional units.
• Using non-contemporaneous measurements.
• Treating the output as a diagnosis or prescription.

Evidence Base

The implemented calculation follows the published or guideline-based relationship: FAI = total testosterone ÷ SHBG × 100.

References

1. Vermeulen A, et al. A critical evaluation of simple methods for the estimation of free testosterone. J Clin Endocrinol Metab. 1999. — Primary publication, guideline or established source supporting the calculation.