Calculates the aggregate index of systemic inflammation from neutrophils, monocytes, platelets and lymphocytes.
Aggregate Index of Systemic Inflammation: Clinical Guide
Browse Knowledge HubCalculates the aggregate index of systemic inflammation from neutrophils, monocytes, platelets and lymphocytes.
Overview
Calculates the aggregate index of systemic inflammation from neutrophils, monocytes, platelets and lymphocytes.
Clinical Significance
An investigational inflammatory index. It should be interpreted only within a validated disease-specific context.
How It Is Calculated
- AISI = neutrophils × monocytes × platelets / lymphocytes.
Interpretation
- An investigational inflammatory index. It should be interpreted only within a validated disease-specific context.
Worked Example
Enter a clinically consistent set of values in the displayed units. MedicalC applies: AISI = neutrophils × monocytes × platelets / lymphocytes.
Limitations
- This tool does not establish a diagnosis or mandate treatment.
- Published cut-offs may vary between cohorts and measurement methods.
- Calculation precision cannot compensate for poor source data.
Clinical Pearls
- Trend the result over time where clinically appropriate.
- Record the source values and units alongside the calculated result.
Common Mistakes
- Using the wrong unit.
- Combining measurements obtained at different times.
- Applying a research-derived threshold as a universal treatment trigger.
Frequently Asked Questions
What does this calculator provide?
Calculates the aggregate index of systemic inflammation from neutrophils, monocytes, platelets and lymphocytes.
Can this result be used alone?
No. It must be interpreted with clinical context and appropriate investigations.
What equation is used?
AISI = neutrophils × monocytes × platelets / lymphocytes.
What is the main limitation?
The result depends on valid inputs and may not be calibrated for every population or setting.
References
- Observational literature on aggregate index of systemic inflammation. — Formula, physiological or validation reference.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.