Classifies pulmonary arterial hypertension risk using WHO functional class, 6-minute walk distance and natriuretic peptide level.
COMPERA 2.0 Four-Strata PAH Risk: Clinical Guide
Browse Knowledge HubClassifies pulmonary arterial hypertension risk using WHO functional class, 6-minute walk distance and natriuretic peptide level.
Overview
Classifies pulmonary arterial hypertension risk using WHO functional class, 6-minute walk distance and natriuretic peptide level.
Clinical Significance
Rounded mean grades define low (1), intermediate-low (2), intermediate-high (3) or high (4) risk.
When to Use
- Use as structured clinical decision support when the required data are available and reliable.
How It Is Calculated
- The displayed variables are combined using the published equation, decision rule or weighted point system.
Interpretation
- Rounded mean grades define low (1), intermediate-low (2), intermediate-high (3) or high (4) risk.
Worked Example
Enter verified patient data in the displayed units; MedicalC applies the published model.
Limitations
- Risk and classification tools can be misapplied outside their validated population.
- Missing, estimated or non-contemporaneous data may materially change the result.
Clinical Pearls
- Document the input values, units, date and clinical setting with the result.
- Use serial scores only when the same instrument and measurement method are used consistently.
Common Mistakes
- Using the tool without confirming entry criteria.
- Using approximate or incorrectly converted laboratory values.
- Treating a prognostic score as a standalone treatment decision.
Frequently Asked Questions
What does this tool calculate?
Classifies pulmonary arterial hypertension risk using WHO functional class, 6-minute walk distance and natriuretic peptide level.
Can this result be used alone?
No. Interpret it with the full clinical assessment, applicable entry criteria and current guidance.
References
- Hoeper MM et al. Eur Respir J. 2022;60:2102311. — Primary or supporting reference for the implemented model.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.