Calcium–Creatinine Clearance Ratio: Clinical Guide

Overview

Calculates the calcium–creatinine clearance ratio used in hypercalcaemia assessment.

Clinical Significance

Low values may support familial hypocalciuric hypercalcaemia but overlap is substantial.

When to Use

• Use as decision support when all required inputs are reliable.

How It Is Calculated

• CCCR = (urine calcium × serum creatinine)/(serum calcium × urine creatinine), with consistent molar units.

Interpretation

• Low values may support familial hypocalciuric hypercalcaemia but overlap is substantial.

Worked Example

Enter verified values in the displayed units; MedicalC applies the published equation or point system.

Limitations

• Prediction models may be miscalibrated outside their derivation population.
• Measurement and classification error can materially change the result.

Clinical Pearls

• Document source values and units with the result.
• Use trends and the full clinical picture.

Common Mistakes

• Wrong units.
• Using non-contemporaneous inputs.
• Treating the output as a diagnosis or mandatory treatment decision.

References

1. Christensen SE et al. Clin Endocrinol (Oxf). 2008;69:713-720. — Primary or supporting reference for the implemented model.