Global Antiphospholipid Syndrome Score (GAPSS): Clinical Guide

Clinical guide to Global Antiphospholipid Syndrome Score (GAPSS) including calculation, interpretation, assumptions, limitations and references.

Estimates thrombotic and pregnancy morbidity risk in antiphospholipid syndrome.

Overview

Estimates thrombotic and pregnancy morbidity risk in antiphospholipid syndrome.

Clinical Significance

Higher GAPSS values indicate a greater antiphospholipid-related thrombotic risk burden.

When to Use

  • Use as structured clinical decision support when the required data are available and reliable.

How It Is Calculated

  • The displayed variables are combined using the published equation, decision rule or weighted point system.

Interpretation

  • Higher GAPSS values indicate a greater antiphospholipid-related thrombotic risk burden.

Worked Example

Enter verified patient data in the displayed units; MedicalC applies the published model.

Limitations

  • Risk and classification tools can be misapplied outside their validated population.
  • Missing, estimated or non-contemporaneous data may materially change the result.

Clinical Pearls

  • Document the inputs, units, date and clinical setting with the result.
  • Use serial scores only when the same instrument and measurement method are used consistently.

Common Mistakes

  • Using the tool without confirming entry criteria.
  • Using approximate or incorrectly converted values.
  • Treating a prognostic score as a standalone treatment decision.

Frequently Asked Questions

What does this tool calculate?

Estimates thrombotic and pregnancy morbidity risk in antiphospholipid syndrome.

Can this result be used alone?

No. Interpret it with the full clinical assessment, applicable entry criteria and current guidance.

References

  1. Sciascia S et al. Rheumatology. 2013;52:1397-1403. — Primary or supporting reference for the implemented model.

Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026

Return to calculator