CLIF-C ACLF Score Calculator

Estimates mortality in acute-on-chronic liver failure using CLIF organ-failure score, age and white-cell count. Includes interpretation, information buttons and a clinical guide.

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CLIF-C ACLF Score
Clinical Decision Tool

Estimates mortality in acute-on-chronic liver failure using CLIF organ-failure score, age and white-cell count.

Enter the clinically verified value.
Enter the clinically verified value.
Enter the clinically verified value.
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Clinical Decision Support Only

MediCalc calculators are intended to support qualified healthcare professionals and must not replace professional clinical judgement. Do not enter patient-identifiable information into Saved Progress.

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MedicalC Knowledge Hub

CLIF-C ACLF Score: Clinical Guide

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Estimates mortality in acute-on-chronic liver failure using CLIF organ-failure score, age and white-cell count.

Overview

Estimates mortality in acute-on-chronic liver failure using CLIF organ-failure score, age and white-cell count.

Clinical Significance

Higher scores indicate higher short-term mortality; scores ≥70 identify an extremely high-risk group in appropriate clinical context.

When to Use

  • Use as structured clinical decision support when the required data are available and reliable.

How It Is Calculated

  • The displayed variables are combined using the published equation, decision rule or weighted point system.

Interpretation

  • Higher scores indicate higher short-term mortality; scores ≥70 identify an extremely high-risk group in appropriate clinical context.

Worked Example

Enter verified patient data in the displayed units; MedicalC applies the published model.

Limitations

  • Risk and classification tools can be misapplied outside their validated population.
  • Missing, estimated or non-contemporaneous data may materially change the result.

Clinical Pearls

  • Document the input values, units, date and clinical setting with the result.
  • Use serial scores only when the same instrument and measurement method are used consistently.

Common Mistakes

  • Using the tool without confirming entry criteria.
  • Using approximate or incorrectly converted laboratory values.
  • Treating a prognostic score as a standalone treatment decision.

Frequently Asked Questions

What does this tool calculate?

Estimates mortality in acute-on-chronic liver failure using CLIF organ-failure score, age and white-cell count.

Can this result be used alone?

No. Interpret it with the full clinical assessment, applicable entry criteria and current guidance.

References

  1. Jalan R et al. J Hepatol. 2014;61:1038-1047. — Primary or supporting reference for the implemented model.

Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026

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Reviewed by: MedicalC Clinical Editorial Team Last reviewed: July 2026

Clinical Disclaimer

MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.

Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.

Reviewed by: MedicalC Clinical Editorial Team Last reviewed: July 2026
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