Supports assessment of heart failure with preserved ejection fraction using functional, morphological and biomarker domains.
HFA–PEFF Diagnostic Score: Clinical Guide
Browse Knowledge HubSupports assessment of heart failure with preserved ejection fraction using functional, morphological and biomarker domains.
Overview
Supports assessment of heart failure with preserved ejection fraction using functional, morphological and biomarker domains.
Clinical Significance
Scores 0–1 make HFpEF unlikely, 5–6 support HFpEF, and 2–4 require functional testing.
When to Use
- Use as decision support when all required inputs are reliable.
How It Is Calculated
- Each domain contributes 0, 1 or 2 points; total 0–6.
Interpretation
- Scores 0–1 make HFpEF unlikely, 5–6 support HFpEF, and 2–4 require functional testing.
Worked Example
Enter verified values in the displayed units; MedicalC applies the published equation or point system.
Limitations
- Prediction models may be miscalibrated outside their derivation population.
- Measurement and classification error can materially change the result.
Clinical Pearls
- Document source values and units with the result.
- Use trends and the full clinical picture.
Common Mistakes
- Wrong units.
- Using non-contemporaneous inputs.
- Treating the output as a diagnosis or mandatory treatment decision.
Frequently Asked Questions
What does this tool calculate?
Supports assessment of heart failure with preserved ejection fraction using functional, morphological and biomarker domains.
Can the result be used alone?
No. Interpret it with the complete clinical assessment and current guidance.
References
- Pieske B et al. Eur Heart J. 2019;40:3297-3317. — Primary or supporting reference for the implemented model.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.
