Estimates 2- and 5-year treated kidney failure risk in CKD stages G3–G5.
Kidney Failure Risk Equation — 4 Variable: Clinical Guide
Browse Knowledge HubEstimates 2- and 5-year treated kidney failure risk in CKD stages G3–G5.
Overview
Estimates 2- and 5-year treated kidney failure risk in CKD stages G3–G5.
Clinical Significance
Estimates treated kidney failure risk; calibration differs by region and population.
When to Use
- Use as decision support when all required inputs are reliable.
How It Is Calculated
- North American 4-variable KFRE equation using age, sex, eGFR and urine ACR.
Interpretation
- Estimates treated kidney failure risk; calibration differs by region and population.
Worked Example
Enter verified values in the displayed units; MedicalC applies the published equation or point system.
Limitations
- Prediction models may be miscalibrated outside their derivation population.
- Measurement and classification error can materially change the result.
Clinical Pearls
- Document source values and units with the result.
- Use trends and the full clinical picture.
Common Mistakes
- Wrong units.
- Using non-contemporaneous inputs.
- Treating the output as a diagnosis or mandatory treatment decision.
Frequently Asked Questions
What does this tool calculate?
Estimates 2- and 5-year treated kidney failure risk in CKD stages G3–G5.
Can the result be used alone?
No. Interpret it with the complete clinical assessment and current guidance.
References
- Tangri N et al. JAMA. 2011;305:1553-1559. — Primary or supporting reference for the implemented model.
Reviewed by: MedicalC Clinical Editorial Team
Last reviewed: July 2026
Clinical Disclaimer
MedicalC calculators and clinical tools are intended to support healthcare professionals. They do not replace clinical judgement, individual patient assessment, local guidance or specialist advice.
Results should always be interpreted in the context of the patient’s history, examination, investigations, current clinical condition and applicable professional guidance.